CRF reflects complex improvements in vascular, cardiac, and metabolic health from aerobic exercise. The SECOND AIM is to determine the mechanism of LTAE effects in PD. Driving represents an important symbol for independence, and depends on integrity of cognitive and motor systems. The investigators will use driving as the outcome for IADL.
Koreografi s aerobick trial#
The investigators will test this with a one-year randomized controlled trial (RCT) that compares the effects of moderate aerobic exercise vs usual care. The investigators hypothesize that LTAE will provide sustained improvement in motor function, cognition, and non-motor symptoms with translation of benefits to QoL and IADL. The investigators' prior 6-month, uncontrolled trial showed preliminary evidence that aerobic exercise improves aspects of motor function, cognition, and QoL in PD, but long term outcomes and implication for functional abilities are unknown. The FIRST AIM is to determine the effects of LTAE on clinical features and functional abilities in PD. The overall hypothesis is that LTAE improves brain tissue integrity and slows down PD. The objective in this application is to fill the translational gap by determining the biological, clinical, and functional effects of long term aerobic exercise (LTAE) in PD. Limitations of current studies include short duration, small sample size, lack or inadequacy of controls, lack of outcome measures for cognition and IADL, and lack of biological markers to measure progression.
![koreografi s aerobick koreografi s aerobick](https://classpass-res.cloudinary.com/image/upload/f_auto/q_auto/jdv4kxwpkko2ojujhba6.jpg)
It is unknown if aerobic exercise is more beneficial than usual care in PD in long term due to gaps in the investigators knowledge about the effects of cardiorespiratory fitness (CRF) on brain tissue integrity, motor function, cognition, IADL, QoL, and disease progression. However, aerobic exercise is demanding and carries some risks. Preliminary research suggests that aerobic exercise has potential to meet this need. Thus, there is a critical need for treatments that provide broad spectrum of benefits and slow PD. There is no cure or disease modifying treatment. There is no approved standard exercise regimen for PD.
![koreografi s aerobick koreografi s aerobick](https://images-na.ssl-images-amazon.com/images/S/pv-target-images/1709521440e95fec312ef54c770762aeac4e95c382b8c2bd1f24fe9c9c60d8b4._RI_V_TTW_.jpg)
Physical Therapy is usually prescribed in later stages when mobility impairment ensues. Acetylcholine esterase inhibitors exert modest symptomatic benefits on dementia, but there is no approved treatment for mild cognitive impairment. Usual treatment for non motor manifestations with pharmaceuticals (e.g., antidepressants) is symptomatic and not specific for PD. Usual care of PD centers on medical and surgical treatments relieve motor symptoms, but these cause side effects and lose efficacy over time. DTI shows progressive decline in brain tissue integrity. Non-motor symptoms due to fatigue, mood, sleep, and autonomic disorders further reduce quality of life (QoL). Even early in the course, motor and cognitive dysfunction impairs instrumental activities of daily living (IADL). Parkinson's disease (PD) culminates in dementia, immobility, and death at a huge societal cost. Condition or diseaseīehavioral: Aerobic walking Behavioral: Usual care with PD specific health education If effective, aerobic exercise can be implemented immediately as a low cost, easily accessible treatment in PD. The investigators will conduct a clinical trial to test the long term effects of aerobic exercise on the brain tissue, movement, mental functions, and driving in PD. However, due to limited and inconsistent research results, the long term effects of aerobic exercise on brain health and clinical features in PD is unknown. Animal and preliminary human studies on aerobic exercise show promising results in helping a broad spectrum of symptoms. Drugs provide limited and temporary benefit for cognition and do not prevent dementia. Although drugs and surgery help movement problems, their benefits are temporary and may cause side effects. As a result, patients lose critical abilities such as driving and can become isolated. PD places an unbearable burden on the individual due to progressive impairment of movement and mental function.
![koreografi s aerobick koreografi s aerobick](https://mufit.id/admin/uploads/image/aerobic-2.jpg)
Parkinson's disease (PD) is an incurable brain illness that afflicts more than one million Americans, including many aging Veterans. Why Should I Register and Submit Results?.
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